Going out of the airport, take the free way towards Funchal, keep driving about 20 km till you find the exit to Hospital/Porto/Funchal, take that exit and keep going down till the roundabout (you will see the hospital in your right hand side), keep going down till the 3rd traffic light, turn right, after the bridge, turn right, keep going up till the roundabout, take the exit on the left (you will be entering the Rua da Casa Branca), drive around 100 metres, right after the curve, you will see the entrance to the Estalagem Quinta da Casa Branca.